abstract：:In people with Huntington's disease, an expanded CAG repeat sequence on the HTT gene confers a toxic gain function resulting in a progressive and fatal neurodegeneration. The Hdh((CAG)Q150) Huntington's disease mouse line is a knock-in model of the disease that carries ∼150 CAG repeats on the normal mouse Htt locus. T...

journal_title：Brain research bulletin

authors： Brooks S,Higgs G,Jones L,Dunnett SB

更新日期：2012-06-01 00:00:00

abstract：:Nogo, also known as Reticulon-4, is a protein that is specific to the central nervous system (CNS), and has been identified as an inhibitor of neurite outgrowth. Nogo-A is the largest member of the Nogo family and is responsible for inhibition of CNS regeneration. The structural information and biological functions of...

journal_title：Brain research bulletin

authors： Wang T,Xiong JQ,Ren XB,Sun W

更新日期：2012-04-10 00:00:00

abstract：:Methylphenidate (MPD) is currently one of the most prescribed drug therapies for attention deficit/hyperactivity disorder (ADHD) and moreover is abused for cognitive enhancement and used for recreation by the young and adults. Methylphenidate is used for prolonged periods of time and its mechanism of action on the bra...

journal_title：Brain research bulletin

authors： Claussen C,Dafny N

更新日期：2012-03-10 00:00:00

abstract：:Methylphenidate (MPD) is a psychostimulant that enhances dopaminergic neurotransmission in the central nervous system by using mechanisms similar to cocaine and amphetamine. The mode of action of brain circuitry responsible for an animal's neuronal response to MPD is not fully understood. The nucleus accumbens (NAc) h...

journal_title：Brain research bulletin

authors： Chong SL,Claussen CM,Dafny N

更新日期：2012-03-10 00:00:00

abstract：:Traumatic brain injury (TBI) is a major public-health problem for which mild TBI (MTBI) makes up majority of the cases. MTBI is a poorly-understood health problem and can persist for years manifesting into neurological and non-neurological problems that can affect functional outcome. Presently, diagnosis of MTBI is ba...

journal_title：Brain research bulletin

authors： Kan EM,Ling EA,Lu J

更新日期：2012-03-10 00:00:00

abstract：:Depression is a brain disorder and there is still only a partial understanding of its underlying pathophysiology. Antidepressant medications with a fast onset have not yet been developed. In addition to the monoaminergic systems, the brain glutaminergic system has been implicated in the etiology of depression. Animal ...

journal_title：Brain research bulletin

authors： Kovačević T,Skelin I,Minuzzi L,Rosa-Neto P,Diksic M

更新日期：2012-03-10 00:00:00

abstract：:Fatty acid amide hydrolase (FAAH) is an enzyme that metabolizes endocannabinoids and fatty acid amides possibly linked to activation of the opioid system. To examine how this enzyme affects spinal signalling, electrophysiological recordings in the dorsal horn and qPCR on dorsal horn tissue following systemic administr...

journal_title：Brain research bulletin

authors： Eriksen GS,Jacobsen LM,Mahmood A,Pedersen LM,Gjerstad J

更新日期：2012-02-10 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are promising donor cells for transplantation therapies for a variety of diseases. However, there still lack efficient ways to induce directional differentiation of BMSCs to promote their practical use in transplantation therapy. In this study, we constructed hybrid cells by transferr...

journal_title：Brain research bulletin

authors： Zhou Z,Xu Y,Zhong Q,Zheng J

更新日期：2012-02-10 00:00:00

abstract：:Scientific reports suggest that the exposure to long-term stressors throughout or during late gestation increase anxiety- and depression-like behaviors of offspring in their later life. Moreover, several studies concluded that increasing age correlates with increased anxiety behaviors in humans and rodents. In the pre...

journal_title：Brain research bulletin

authors： Enayati M,Solati J,Hosseini MH,Shahi HR,Saki G,Salari AA

更新日期：2012-02-10 00:00:00

abstract：:Inflammation and oxidative stress play an important role in cerebral ischemic pathogenesis. Polydatin has been proved to elicit numerous biological effects through its anti-inflammatory and anti-oxidant properties. However, little is known regard to the mechanism of polydatin's neuroprotection in ischemic stroke. We t...

journal_title：Brain research bulletin

authors： Ji H,Zhang X,Du Y,Liu H,Li S,Li L

更新日期：2012-01-04 00:00:00

abstract：:Spinal astrocytes have emerged as important mechanistic contributors to pathological and chronic pain. Recently, we have demonstrated that injection of diluted bee venom (DBV) into the Zusanli (ST36) acupoint produces a potent anti-nociceptive effect via the activation of spinal alpha-2 adrenoceptors. However, it is u...

journal_title：Brain research bulletin

authors： Kang SY,Kim CY,Roh DH,Yoon SY,Park JH,Lee HJ,Beitz AJ,Lee JH

更新日期：2011-11-25 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) has been reported to be up-regulated in the hypothalamic supraoptic nucleus (SON) during dehydration which in turn could increase nitric oxide (NO) production and consequently affect arginine vasopressin (AVP) secretion. The anteroventral third ventricle (AV3V) region has strong a...

journal_title：Brain research bulletin

authors： Aguila FA,Oliveira-Pelegrin GR,Yao ST,Murphy D,Rocha MJ

更新日期：2011-10-10 00:00:00

abstract：:Although the huge economic and social impact and the predicted incidence increase, neuroprotection for ischemic stroke remains as a therapeutically empty niche. In the present study, we investigated the rationale of the C-Phycocyanin (C-PC) treatment on global cerebral ischemia/reperfusion (I/R) injury in gerbils. We ...

journal_title：Brain research bulletin

authors： Pentón-Rol G,Marín-Prida J,Pardo-Andreu G,Martínez-Sánchez G,Acosta-Medina EF,Valdivia-Acosta A,Lagumersindez-Denis N,Rodríguez-Jiménez E,Llópiz-Arzuaga A,López-Saura PA,Guillén-Nieto G,Pentón-Arias E

更新日期：2011-08-10 00:00:00

abstract：:Postpartum female rats exhibit a suppression of anxiety-related behaviors when compared to diestrous virgin females, pregnant females, and males. This blunted anxiety promotes optimal maternal care and involves elevated GABA neurotransmission, possibly including greater density of GABA(A) and benzodiazepine receptors ...

journal_title：Brain research bulletin

authors： Miller SM,Lonstein JS

更新日期：2011-08-10 00:00:00

abstract：:Since years there is a hotly discussed dispute whether event-related potentials are either generated by an evoked component or by resetting of ongoing phase. We argue that phase-reset must not be proven in order to accept the general involvement of phase in ERP-generation as it is only one of several possible mechanis...

journal_title：Brain research bulletin

authors： Fellinger R,Klimesch W,Gruber W,Freunberger R,Doppelmayr M

更新日期：2011-07-15 00:00:00

abstract：:Chronic stress, a risk factor for the development of psychiatric disorders, is known to induce alterations in neuronal networks in many brain areas. Previous studies have shown that chronic stress changes the expression of the cannabinoid receptor 1 (CB1) in the brains of adult rats, but neurophysiological consequence...

journal_title：Brain research bulletin

authors： Hu W,Zhang M,Czéh B,Zhang W,Flügge G

更新日期：2011-07-15 00:00:00

abstract：:Although increasing evidence indicates that psychiatric symptoms are crucial characteristic of the early stage of Parkinson's disease (PD) and precede motor impairments, the neuronal firing activity of the basolateral nucleus of the amygdala (BLA) in the psychiatric symptom of PD and the involved mechanism are still u...

journal_title：Brain research bulletin

authors： Chen L,Liu J,Zhang QJ,Feng JJ,Gui ZH,Ali U,Wang Y,Fan LL,Hou C,Wang T

更新日期：2011-07-15 00:00:00

abstract：:Intelligence depends on the ability of the brain to acquire and apply rules and representations. At the neuronal level these properties have been shown to critically depend on the prefrontal cortex. Here we present, in the context of the Distributed Adaptive Control architecture (DAC), a biologically based model for f...

journal_title：Brain research bulletin

authors： Duff A,Fibla MS,Verschure PF

更新日期：2011-06-30 00:00:00

abstract：:Hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine (NIC) are sexually diergic: Female rats have higher adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses than do males. In the present study we determined HPA responses in male and female rats following single doses of NIC, a sing...

journal_title：Brain research bulletin

authors： Gentile NE,Andrekanic JD,Karwoski TE,Czambel RK,Rubin RT,Rhodes ME

更新日期：2011-05-30 00:00:00

abstract：:Sigma receptor agonists have been found to provide potent neuroprotection in rats and mice. This neuroprotection is thought to be mediated through anti-excitotoxic mechanisms. Neuroprotective and immune modulatory effects of sigma ligands have not been investigated in embolic stroke. In the present study, rats were su...

journal_title：Brain research bulletin

authors： Allahtavakoli M,Jarrott B

更新日期：2011-05-30 00:00:00

abstract：:The relationship between the "passions" (emotions or feelings) and psychopathology has been a constant throughout the history of medicine. In this context, melancholy was considered a perversion of the soul (corruption of the passions). One of the most influential authors on this subject was René Descartes, who discus...

journal_title：Brain research bulletin

authors： López-Muñoz F,Rubio G,Molina JD,Alamo C

更新日期：2011-04-25 00:00:00

abstract：:Calcitonin, a peptide hormone expressed in C-cells of the thyreoid gland, as well as capsaicin, isolated from chili, both, modify intracellular signalling in nociceptive neurones. The pathways triggered by the activation of either of these receptors results in a modulation of the intracellular calcium ([Ca(2+)](i)) co...

journal_title：Brain research bulletin

authors： Hagenacker T,Ledwig D,Büsselberg D

更新日期：2011-04-25 00:00:00

abstract：:Ca(2+)/calmodulin-dependent kinase II (CaMKII) is an abundant synaptic signalling molecule that is essential for memory formation and the induction of synaptic potentiation. Additionally, CaMKII plays a prominent role in synaptic tagging and metaplasticity. These abilities are mediated by kinase activity as well as bi...

journal_title：Brain research bulletin

authors： Lucchesi W,Mizuno K,Giese KP

更新日期：2011-04-25 00:00:00

abstract：:Fractal nature of the human sleep EEG was revealed recently. In the literature there are some attempts to relate fractal features to spectral properties. However, a comprehensive assessment of the relationship between fractal and power spectral measures is still missing. Therefore, in the present study we investigated...

journal_title：Brain research bulletin

authors： Weiss B,Clemens Z,Bódizs R,Halász P

更新日期：2011-04-05 00:00:00

abstract：:An increasing number of studies suggest that nicotine/tobacco addiction is modulated by ovarian hormones. The levels of estrogen and progesterone appear to be important in the success of quit attempts and smoking cessation. In women smokers with the diagnosis or risk of breast cancer, the estrogen receptor modulator t...

journal_title：Brain research bulletin

authors： Yararbas G,Pogun S

更新日期：2011-04-05 00:00:00

abstract：:Inducing significant axon growth or regeneration after spinal cord injury has been difficult, primarily due to the poor growth supportive environment and low intrinsic growth ability of neurons within the CNS. Neurotrophins alone have been shown to readily induce regeneration of sensory axons after dorsal root lesions...

journal_title：Brain research bulletin

authors： Smith GM,Onifer SM

更新日期：2011-03-10 00:00:00

abstract：:Cocaine is a major stimulant drug which can have rewarding and locomotor activating effects. It is used by non-addicts to enhance concentration and performance in a work or social setting. It was suggested that cocaine may amplify the impact of mood and sensory stimulation on behaviour. Here we tested whether cocaine ...

journal_title：Brain research bulletin

authors： Pum ME,Rubio AR,Carey RJ,Silva MA,Müller CP

更新日期：2011-02-28 00:00:00

abstract：:It has been suggested that the primary motor cortex plays a substantial role in the neural circuitry that controls swallowing. Although its role in the voluntary oral phase of swallowing is undisputed, its precise role in motor control of the more reflexive, pharyngeal phase of swallowing is unclear. The contribution ...

journal_title：Brain research bulletin

authors： Doeltgen SH,Ridding MC,Dalrymple-Alford J,Huckabee ML

更新日期：2011-01-15 00:00:00

abstract：:Intra-arterial administration of papaverine has been revealed to cause an increase in the blood-brain tumor barrier (BTB) permeability. The exact mechanism of papaverine opening the BTB in chemotherapy of malignant cerebral tumors, however, has not been well described. We used a rat brain glioma (C6) model for studyin...

journal_title：Brain research bulletin

authors： Wang ZH,Xue YX,Liu YH

更新日期：2010-11-20 00:00:00

abstract：:Mutations in PLA2G6, which encodes calcium-independent phospholipase A(2) group VIA (iPLA2-VIA), underlie the autosomal recessive disorder infantile neuroaxonal dystrophy (INAD). INAD typically presents in the first year of life, and leads to optic atrophy and psychomotor regression. We have examined PLA2G6 expression...

journal_title：Brain research bulletin

authors： Polster B,Crosier M,Lindsay S,Hayflick S

更新日期：2010-11-20 00:00:00

abstract：:Excitatory amino acid transporters (EAATs) represent a group of high affinity glutamate transporters that are involved in the regulation of extracellular glutamate levels at glutamatergic synapses. EAAT proteins have been found on neurons as well as on glia cells where they act synergistically to remove the released g...

journal_title：Brain research bulletin

authors： Gesemann M,Maurer CM,Neuhauss SC

更新日期：2010-10-30 00:00:00

abstract：:In vitro and in vivo studies have demonstrated that lithium treatment can protect neurons against excitotoxic and ischemic damage. Yet the possible beneficial effect of chronic low dose lithium on a model of traumatic brain injury (TBI) has not been intensively investigated. In this study, lithium (1 mmol/kg) was give...

journal_title：Brain research bulletin

authors： Zhu ZF,Wang QG,Han BJ,William CP

更新日期：2010-10-30 00:00:00

abstract：:Schizophrenia (SZ) is a common and severe psychiatric disorder with both environmental and genetic risk factors, and a high heritability. After over 20 years of molecular genetics research, new molecular strategies, primarily genome-wide association studies (GWAS), have generated major tangible progress. This new data...

journal_title：Brain research bulletin

authors： Duan J,Sanders AR,Gejman PV

更新日期：2010-09-30 00:00:00

abstract：:Neonatal post-hemorrhagic hydrocephalus is associated with cognitive decline and a serious deterioration in the patient's quality of life. The underlying impairments to neurons are not well understood. Here, we used the method described by Cherian et al. to construct a model of hydrocephalus after intra-ventricular he...

journal_title：Brain research bulletin

authors： Chen X,Huang X,Li B,Zhao Z,Jiang L,Huang C,Lu Y

更新日期：2010-08-30 00:00:00

abstract：:Evidence exists that nitric oxide (NO) may mediate both protective and pathological responses during brain hypoxia (HP). Reactive oxygen species have also been implicated in the pathophysiological response of the brain tissues to HP. Therefore, this study investigated whether a NO precursor, l-arginine (l-arg), a free...

journal_title：Brain research bulletin

authors： Abdel Baky NA,Zaidi ZF,Fatani AJ,Sayed-Ahmed MM,Yaqub H

更新日期：2010-08-30 00:00:00

abstract：:Trans-2, 4-dimethoxystibene (S3) is a synthetic stilbenes. In the present study, S3 was investigated to assess its neuroprotective effect against the toxicity induced by Abeta(25-35) in hypercholesterolemic rats. Rats were fed with hypercholesterolemic chow for six weeks, and then received a single intracerebroventric...

journal_title：Brain research bulletin

authors： Ruan CJ,Li Z,Zhang L,Chen DH,Du GH,Sun L

更新日期：2010-07-30 00:00:00

abstract：:The increase in life expectancy seen in many countries has been accompanied by an increase in the number of people living with dementia and a growing need for health care. The large number of affected individuals emphasizes the need to identify causes for the phenotypes associated with diseases such as Alzheimer's, Pa...

journal_title：Brain research bulletin

authors： Schengrund CL

更新日期：2010-04-29 00:00:00

abstract：:Calcium/calmodulin-dependent protein-kinase II (CaMKII) is a ubiquitous intracellular enzyme, which is implicated in learning and memory mechanisms in the central nervous system, however its contribution to peripheral cholinergic neurotransmission is not well characterized. This study evaluated the impact of CaMKII on...

journal_title：Brain research bulletin

authors： Mukhamedyarov MA,Kochunova JO,Yusupova ER,Haidarov BA,Zefirov AL,Palotás A

更新日期：2010-04-05 00:00:00

abstract：:The elevated plus-maze is an animal model used to study anxiety. In a second session, rats show a reduction in the exploratory behavior even when the two sessions are separated by intervals as large as 7 days. The aim of the present study was to investigate whether the reduction in the exploratory behavior is maintain...

journal_title：Brain research bulletin

authors： Galvis-Alonso OY,Garcia AM,Orejarena MJ,Lamprea MR,Botelho S,Conde CA,Morato S,Garcia-Cairasco N

更新日期：2010-04-05 00:00:00

abstract：:A growing body of evidence has pointed to the NMDA receptor antagonists as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural and molecular effects of the acute and chronic treatment with memantine and imipramine in rats. To this aim, rats were acu...

journal_title：Brain research bulletin

authors： Réus GZ,Stringari RB,Kirsch TR,Fries GR,Kapczinski F,Roesler R,Quevedo J

更新日期：2010-04-05 00:00:00